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DNA Celiac Disease Test

Almost all people with celiac disease carry at least one genetic risk allele. Find out what your risk with this DNA test.

• Includes HLA variants associated with increased risk

• Negative results rules out celiac disease for life

• Accurate even on gluten-free diet

• No age limit

• 24/7 online status check

• Are you at increased risk of celiac disease?

   Detailed Description

What is celiac disease?

Celiac disease is an autoimmune disorder, where the immune system attacks and destroys healthy cells by mistake. People with celiac disease (CD) are extremely sensitive to gluten, a protein found in wheat, rye, barley and oats.

When an individual with CD consumes gluten, their immune system reacts aberrantly, causing severe damage to the lining of the small intestine, and a variety of health complications.

The consumption of gluten is not needed for an accurate result from this genetic analysis. A simple mouth swab DNA sample is all that is required.

The Genetics

Almost all people with celiac disease have at least one genetic risk allele in their HLA genes. This DNA test detects nucleotide changes that occur in the three CD-associated alleles of the HLA-DQA1 and HLA-DQB1 genes (HLA-DQA1*05, HLA-DQB1*02, HLA-DQB1*0302).

These CD-associated variants can also pair together to form proteins known as DQ2 and DQ8. The presence or absence of these variants gives an indication of the risk of gluten sensitivity and CD.

The risk of CD is extremely low if none of these CD-associated alleles are present.

Patient Genotype (celiac-associated alleles present) Celiac Disease Risk
DQ2 and DQ8 1:7
DQ2 and Homozygous HLA-DQB1*02 1:10
DQ2 and DQ2 1:10
DQ8 and DQ8 1:12
DQ8 and HLA-DQB1*02 1:24
Homozygous HLA-DQB1*02 1:26
DQ2 1:35
DQ8 1:89
Heterozygous HLA-DQB1*02 1:210
HLA-DQA1*05 1:1842
No HLA celiac-associated alleles detected Not at risk of developing celiac disease, less than 1:2518

• Flatulenc
 
• Bloating

• Constipation and/or diarrhea

• Appetite changes

• Pale or bloody stools

• Nausea and vomiting

 How It Works

Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online

NOTE: Please provide your email address for reporting.



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