APOE Cardiovascular Disease DNA Test – At-Home Heart Health Genetic Risk Kit

APOE Cardiovascular Disease DNA Test – Know Your Genetic Risk for Heart Disease

Your APOE gene plays a major role in how your body manages cholesterol — and your risk of cardiovascular disease (CVD). This at-home DNA test identifies your APOE genotype (e2, e3, or e4) so you can understand your personal risk for high LDL-cholesterol, atherosclerosis, and heart disease, and discover the most effective strategies to protect your heart health. All from a simple, painless cheek swab at home.

Key Benefits

• Identifies your APOE genotype (e2, e3, e4) and cardiovascular disease risk
• Reveals your genetic predisposition to high LDL-cholesterol and atherosclerosis
• Screens for hyperlipoproteinemia type III risk (elevated triglycerides)
• Guides the most effective dietary and medication strategies for your genotype
• Painless buccal (cheek swab) sample collection — no needles or clinic visit
• Results in 1–3 business days after laboratory receipt
• 24/7 online test status tracking
• Private, confidential, and secure
• No age limit

What Is Cardiovascular Disease?

Cardiovascular disease (CVD) includes heart attack, stroke, and atherosclerosis. A key driver of CVD is elevated LDL-cholesterol — often called “bad” cholesterol — which accumulates in blood vessel walls, causing blockages and scarring. Elevated triglycerides and other low-density lipoproteins also contribute to CVD risk. Hyperlipoproteinemia type III, characterized by elevated triglycerides and beta-very low-density lipoproteins, is one such condition associated with early-onset peripheral vascular disease and CVD.

The Genetics – Understanding Your APOE Alleles

The APOE gene encodes Apolipoprotein E (ApoE), a protein central to cholesterol production, delivery, and utilization in the body. There are three common alleles — e2, e3, and e4 — each producing a slightly different version of the ApoE protein with distinct effects on cardiovascular risk:

• e3 (most common): Neutral allele — no increased or decreased risk of CVD
• e4: Associated with elevated LDL-cholesterol and increased risk of atherosclerosis and CVD
• e2: Associated with lower LDL-cholesterol, but increased risk of high blood sugar and hyperlipoproteinemia type III, which can contribute to CVD

How Your APOE Genotype Affects Your CVD Risk

• e3/e3: Not at increased risk of CVD
• e3/e2: Not at increased risk of CVD
• e2/e2: Lower LDL-cholesterol but increased risk of hyperlipoproteinemia type III, which can contribute to CVD
• e4/e3 or e4/e4: Elevated LDL-cholesterol and increased risk of CVD

How It Works

1. Order your kit online and receive it at home
2. Register and activate your kit online, then collect your DNA sample using the painless cheek swab provided
3. Mail your sample to the lab in the prepaid return envelope
4. Receive your results securely online within 1–3 business days