TheAPOEgene influences both your risk of a heart attack, and your best approach to lower cholesterol levels. Find out your risk and the best treatment option for you.
Examines variants of theAPOEgene
Thee2allele associated with an increased risk of hyperlipoproteinemia type III
Thee4allele linked to high LDL-cholesterol & increased risk of heart disease
Uncover the most effective ways to improve your heart health
Cardiovascular diseases (CVD) include heart attack and stroke. Maintaining normal cholesterol levels is essential for the prevention of CVD.
LDL-cholesterol is often referred to as the “bad” cholesterol. It collects in the walls of your blood vessels, where it can cause blockages and scarring known as atherosclerosis. Increased LDL-cholesterol levels put you at greater risk for CVD.
Other contributing factors to CVD include elevated triglycerides (the main form of storage fat in our body) and high levels of other low-density lipoproteins (e.g. beta-very low-density lipoproteins).
Hyperlipoproteinemia type III is one disease characterized by elevated triglycerides and beta-very low-density lipoproteins. It is associated with an early onset of peripheral vascular disease and CVD.
TheAPOE gene is a major genetic risk factor involved in CVD. It can also influence how well you will respond to dietary changes and blood pressure lowering medications to control your cholesterol levels. A simple mouth swab is all we need to determine your APOE genotype.
The APOE gene is a major genetic risk factor involved in cardiovascular disease. It encodes Apolipoprotein E (ApoE), a protein involved in the production, delivery, and utilization of cholesterol in the body.
Different Versions Of The APOE Gene:
There are several different versions or alleles of APOE. The three most common alleles are known ase2,e3ande4. Each of these alleles produces a slightly different version of the ApoE protein.
e3: The most common, neutral allele. No increased or decreased risk of cardiovascular disease
e4: Associated with an increased risk of high LDL-cholesterol levels and atherosclerosis
e2: Associated with lower LDL-cholesterol levels in the blood, but increased risk of high blood sugar and hyperlipoproteinemia type III, leading to a higher risk of cardiovascular disease
How Does Your APOE Genotype Influence Your Risk of Cardiovascular Disease?
Two copies of thee3allele: Not at increased risk of CVD
Onee3allele and onee2allele: Not at increased risk of CVD
Two copies of thee2allele: Lower LDL-cholesterol but increased risk of hyperlipoproteinemia type III, which can contribute towards CVD
One or two copies of thee4allele: Elevated LDL-cholesterol and increased risk of CVD
Different versions of the APOE gene will also affect how a person responds to diet and statins (cholesterol-lowering drugs).
APOE e3/e4 and e4/e4 genotypes:
Alow-fat dietis recommended for people with thee3/e4ande4/e4genotypes, as they are not able to metabolize fats very effectively. These individualsdo not respond very well to statins.
APOE e2/e2 or e2/e3 genotypes:
Individuals with thee2/e2ore2/e3genotype are able to metabolize fats more efficiently, but have less effective metabolism of carbohydrates. They have abetter response to statins.
How It Works
Step 1: Order test kit online Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope Step 3: Receive your results online
NOTE: Please provide your email address for reporting results.