DNA Alcohol Intolerance Test

DNA Alcohol Intolerance Test – Understand Your Genetic Response to Alcohol

The DNA Alcohol Intolerance Test by Genovate reveals how your genetic makeup affects your body's response to alcohol. Whether you've experienced discomfort after a few sips of wine or wondered why a single beer leaves you feeling unwell, this test provides clarity.

• Examines ADH and ALDH variants that influence alcohol metabolism
• Understand your body's response to alcohol
• Easy and convenient mouth swab sample collection

What is Alcohol Intolerance?

Alcohol intolerance is a genetic condition that affects the body's ability to efficiently metabolize alcohol. Individuals with alcohol intolerance may experience adverse reactions such as facial flushing, nausea, dizziness, and increased heart rate after consuming even small amounts of alcohol.

These reactions are caused by the accumulation of acetaldehyde, a toxic byproduct of alcohol metabolism, due to genetic variations in the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) enzymes.

How is Alcohol Metabolized?

The majority of alcohol is metabolized in the body through a two-step process involving the ADH and ALDH enzymes. In the first step, ADH converts ethanol (the chemical in alcohol) to acetaldehyde — a toxic substance. Then, acetaldehyde is further metabolized to acetate by ALDH, rendering it harmless.

Genetic variations in the ADH1B, ADH1C, and ALDH2 genes can affect the rate of these reactions, leading to an accumulation of acetaldehyde and resulting in the symptoms of alcohol intolerance.

The Genetics

The Genovate Alcohol Intolerance DNA Test analyzes variants in three genes: ADH1B, ADH1C, and ALDH2. These genes encode enzymes involved in the metabolism of alcohol.

• ADH1B and ADH1C: Variants in these genes can increase the activity of the ADH enzyme, leading to a faster conversion of ethanol to acetaldehyde and causing symptoms of alcohol intolerance.
• ALDH2: A common variant in the ALDH2 gene decreases the activity of the ALDH enzyme, slowing the conversion of acetaldehyde to acetate and exacerbating symptoms of alcohol intolerance.

Symptoms of Alcohol Intolerance

If you are genetically predisposed to alcohol intolerance, consuming alcohol may pose significant health risks. Immediate reactions may include facial flushing, nausea, dizziness, headaches, increased heart rate, insomnia, and severe hangovers. Moreover, increased risk of esophageal cancer, cardiovascular problems, memory loss, and psychological issues further emphasize the potential health consequences.

This information is intended for educational purposes only and should not replace professional medical advice. Always consult with a healthcare professional for personalized advice.

How It Works

Step 1: Order the DNA Alcohol Intolerance test online. Enjoy the convenience of having the kit delivered straight to your doorstep.
Step 2: Register and activate your kit online, then collect your DNA sample using the painless mouth swab included. Place your sample in the prepaid return envelope and mail it to the lab.
Step 3: Once your sample arrives, it will be tested with precision and care. Access your results through the secure online platform — private and confidential.