Does late-onset Alzheimer’s disease run in your family? Find out if you are at risk with this DNA Test.
Detects theAPOE e4variant strongly linked to late-onset Alzheimer’s
Individuals with the variant have a 3X to 15X increased risk
100% private and confidential online results
Are you at increased risk of Alzheimer’s disease?
Alzheimer’s disease (AD) is a progressive brain disorder that gradually destroys memory and other important mental functions. More than 90% of AD cases are the late-onset form, with symptoms not appearing until after 65 years of age.
Two abnormal structures, plaques and tangles, are detected in affected brains. These are the prime suspects for increasing cell death and tissue loss.
Plaques, made of a protein called beta-amyloid, stop the nerve cells from talking to each other. Tangles form when tau, a protein that normally forms parallel strings inside nerve cells, crumbles down into a twisted mess. Without the proper tau tracks, cells are unable to move nutrients and other essential supplies around.
The build up of plaques and tangles are responsible for the cell death, as seen in AD brains. Take this test to find out whether you are at risk, so you can start making changes to keep your brain healthy.
Variation in the APOE gene is the strongest genetic factor influencing the risk of late-onset AD. This gene encodes apolipoprotein E, which is involved in transporting fats, neuronal growth, nerve regeneration, immunoregulation and injury repair in the central nervous system.
Genetic variants identified in this test:
There are three common variants (alleles) of APOE, known ase2,e3ande4. Each of us inherits two copies of the APOE gene. The APOE genotype indicates our risk of late-onset AD:
e2/e2– reduced risk
e2/e3– reduced risk
e2/e4– 3X increased risk
e3/e3– does not affect your risk
e3/e4– 3X increased risk
e4/e4– 10X to 15X increased risk
Understanding your genetic risk for AD can encourage early monitoring and allow drug treatment to begin as soon as possible to delay the progression of the disease.
Warning Signs of Alzheimer's Disease:
Memory loss that disturbs daily life
Challenges in planning or solving problems
Difficulty performing familiar tasks
Confusion with time or place
Trouble understanding visual images or spatial relationships
New problems with words in speaking or writing
Misplacing things and losing the ability to retrace steps
Decreased or poor judgement
Withdrawals from work or social activities
Changes in mood or personality
How It Works
Step 1: Order test kit online Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope Step 3: Receive your results online
NOTE: Please provide your email address for reporting results.