Are you of European ancestry?
Maybe you have descended from the Vikings?
People of Viking ancestry are more likely to carry HFE mutations that increase the risk of hereditary hemochromatosis. Find out if you are at risk with this DNA test.
Hereditary hemochromatosis is the most common genetic disorder in the western world. It’s a disease characterized by absorbing too much iron from the diet. This iron accumulates in organs and tissues, eventually causing organ damage and serious health complications.
While iron accumulates from a young age, the symptoms do not appear until later in life. On average, men develop symptoms between the ages of 30-50, compared to women who are diagnosed after 50, often 10-15 years after menopause.
If detected early, hemochromatosis is easily treated. Treatment includes blood removal every 2 – 4 months to remove excess iron. If a diagnosis is made at later stages after organ damage has occurred, the damages are irreversible.
This DNA test identifies three specific changes in the HFE gene that are associated with an increased risk of hemochromatosis.
Genetic Variants Identified in This Test:
C282Y is the most common mutation, and is associated with the most severe symptoms. H63D and S65C are two other mutations that can increase the risk of hemochromatosis. However, often other precipitating factors (e.g. hepatitis or alcohol abuse) are also required before iron overload occurs.
Understanding your genetic risk for AD can encourage early monitoring and allow drug treatment to begin as soon as possible to delay the progression of the disease.
Likelihood of Symptoms:
To be at an increased risk of hemochromatosis, two defective copies of the HFE gene need to be inherited. Carriers, who have one normal and one defective HFE gene, are generally unaffected.
Although individuals who inherit two defective HFE genes are at increased risk of developing hemochromatosis, many will not show any disease symptoms. Additional modifying genes or other factors (e.g. alcohol abuse) are thought to contribute to the risk of hemochromatosis in genetically susceptible individuals.
Hemochromatosis is hard to diagnose based on physical symptoms alone, because these symptoms are also seen in many other health conditions. Early symptoms include:
Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online
NOTE: Please provide your email address for reporting results.
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