Thrombotic Risk DNA Test

Are you at increased risk of abnormal blood clots?
The DNA Thrombotic Risk Test can tell you just that.

• Includes variants in F5, F2 and MTHFR genes
• 100% private and confidential online results
• Painless sample collection
• Are you at increased risk of life-threatening blood clots?

Detailed Description

Thrombosis is the formation of a blood clot inside a blood vessel, preventing the flow of blood through the circulatory system. Deep vein thrombosis (DVT) is the most common form of venous thrombosis. DVT refers to a clot in a deep vein and it often happens in the leg. Symptoms in the affected area include pain, swelling, redness and warmth.

If you suspect a DVT you should contact a doctor as soon as possible, because sometimes the clot may break loose and travel to other parts of the body.

If the clot travels to the lungs, it can block essential blood vessels. This life-threatening complication is known as a pulmonary embolism (PE). Symptoms include a sudden shortness of breath, chest pain, coughing up blood-streaked mucus and a rapid heartbeat.

If the clot travels to the brain, it can potentially cause a cerebral venous thrombosis. Symptoms include impaired speech, difficulty moving parts of the body, vision problems and severe headaches.

Every year, more people die from a blood-clotting problem than breast cancer and HIV combined. All that is needed is a simple mouth swab to uncover your risk with this DNA test.

The Genetics

Genetic changes in three genes are analyzed in this thrombotic risk test. Each change contributes to an increased risk of thrombosis.

VARIANTS TESTED:

• F5 – the Factor V Leiden mutation (1691G>A)
• F2 – the prothrombin mutation (20210G>A)
• MTHFR – two mutations (677C>T and 1298A>C)

We inherit two copies of each gene – one from each parent. Therefore we can inherit two normal copies of a gene (homozygous normal), two copies that carry a genetic mutation (homozygous mutant), or one normal copy and one mutated copy (heterozygous).

VARIANTS TESTED & THROMBOTIC RISK:

• Factor V Leiden – heterozygous (1691G>A) in F5 gene: 3X–8X increased risk of thrombosis | 2X–11X increased risk of miscarriage
• Factor V Leiden – homozygous (1691G>A) in F5 gene: 10X–80X increased risk of thrombosis | 2X–11X increased risk of miscarriage
• Prothrombin – heterozygous (20210G>A) in F2 gene: 2X–5X increased risk of thrombosis | 2X–3X increased risk of miscarriage
• Prothrombin – homozygous (20210G>A) in F2 gene: >5X increased risk of thrombosis | 2X–3X increased risk of miscarriage
• MTHFR – homozygous (677C>T): Increased risk of thrombosis if folate levels are low
• MTHFR – two mutations (677C>T and 1298A>C): Increased risk of thrombosis if folate levels are low

Reducing Your Risk of a Blood Clot

• Maintain a healthy body weight
• Follow a healthy diet
• Increase your blood flow with exercise
• Avoid extended periods of immobility
• Avoid smoking
• Reduce homocysteine levels by getting plenty of folate and other B vitamins
• Wear compression stockings on long flights
• If your risk is very high, seek medical treatment (e.g. anticoagulants)

How It Works

Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online