DNA Thrombotic Risk Test, At-Home Blood Clot Genetic Screening

DNA Thrombotic Risk Test – Genetic Screening for Blood Clot Risk

The DNA Thrombotic Risk Test analyzes variants in the F5, F2, and MTHFR genes to determine whether you carry genetic mutations associated with an increased risk of abnormal blood clots and thrombosis. A simple, painless cheek swab collected at home is all that is needed to uncover your genetic risk — with 100% private and confidential online results.

• Includes variants in F5, F2, and MTHFR genes
• 100% private and confidential online results
• Painless buccal (cheek) swab sample collection
• Results in 1–3 business days after laboratory receipt

About Thrombosis

Thrombosis is the formation of a blood clot inside a blood vessel, obstructing blood flow through the circulatory system. Deep vein thrombosis (DVT) is the most common form, typically occurring in the leg and causing pain, swelling, redness, and warmth in the affected area.

If a clot breaks loose, it can travel to the lungs and cause a pulmonary embolism (PE) — a life-threatening condition with symptoms including sudden shortness of breath, chest pain, and rapid heartbeat. If it travels to the brain, it can cause cerebral venous thrombosis with symptoms such as impaired speech, vision problems, and severe headaches. Every year, more people die from blood-clotting complications than from breast cancer and HIV combined.

The Genetics

This test analyzes genetic changes in three genes, each contributing to increased thrombosis risk:

• F5 – Factor V Leiden mutation (1691G>A): heterozygous = 3–8x increased risk; homozygous = 10–80x increased risk
• F2 – Prothrombin mutation (20210G>A): heterozygous = 2–5x increased risk; homozygous = greater than 5x increased risk
• MTHFR – Two mutations (677C>T and 1298A>C): increased thrombosis risk when folate levels are low

We inherit two copies of each gene — one from each parent. Depending on whether you inherit zero, one, or two mutated copies, your risk level will vary accordingly.

Reducing Your Risk of a Blood Clot

• Maintain a healthy body weight and follow a balanced diet
• Increase blood flow with regular exercise
• Avoid extended periods of immobility, especially during long flights
• Avoid smoking
• Reduce homocysteine levels by getting adequate folate and B vitamins
• Wear compression stockings on long-haul travel
• If your risk is very high, consult your physician about anticoagulant therapy

Frequently Asked Questions

Does a positive result mean I will develop a blood clot?
Not necessarily. Carrying these gene mutations increases your genetic risk but does not guarantee you will develop thrombosis. Many carriers live without complications. A positive result should be shared with your physician so they can evaluate your overall risk profile and recommend appropriate monitoring or preventive measures.

Who should consider this test?
This test is recommended for individuals with a personal or family history of DVT, pulmonary embolism, or unexplained miscarriages, as well as those planning long-haul travel, surgery, or pregnancy who want to understand their clotting risk in advance.

How is the sample collected?
DNA is collected using a painless buccal (cheek) swab. Simply rub the swab inside your mouth against your cheek for 15 seconds. No needles or clinic visits are required.

How long until results are available?
Results are delivered securely online within 1–3 business days after the laboratory receives your sample.

How It Works

1. Order your DNA Thrombotic Risk Test kit online and have it delivered to your door.
2. Collect your DNA sample using the painless cheek swab provided and mail it to the lab in the prepaid return envelope.
3. Receive your results through our secure online platform — private, confidential, and backed by our quality guarantee.